01 - Preheat oven to 400°F and line a baking sheet with parchment paper or lightly grease it.
02 - Combine smoked paprika, garlic powder, onion powder, dried thyme, dried oregano, cayenne pepper, salt, and black pepper in a small bowl.
03 - Pat salmon fillets dry with paper towels. Brush both sides lightly with olive oil and coat evenly with Cajun spice blend.
04 - Place fillets skin-side down on prepared baking sheet in a single layer.
05 - Whisk together honey, fresh lemon juice, and melted butter in a separate bowl.
06 - Spoon half of the honey glaze evenly over the tops of the salmon fillets. Bake for 10 to 12 minutes, until salmon is nearly cooked through and flakes with a fork.
07 - Remove pan from oven, brush fillets with remaining honey glaze, and broil for 1 to 2 minutes until the glaze caramelizes on top.
08 - Garnish with fresh chopped parsley and serve with lemon wedges as desired.