01 - Combine buttermilk and hot sauce in a large bowl. Add chicken pieces, turning to coat thoroughly. Cover and refrigerate for at least 2 hours, or overnight for optimal flavor development.
02 - Preheat oven to 425°F. Whisk flour, baking powder, baking soda, and salt in a large bowl. Cut in cold butter using a pastry blender or fingertips until mixture resembles coarse crumbs. Stir in buttermilk just until dough comes together.
03 - Turn dough onto a floured surface and gently pat to 1-inch thickness. Cut into rounds with a biscuit cutter. Place on parchment-lined baking sheet and brush tops with extra buttermilk. Bake 12–15 minutes until golden brown.
04 - Mix flour, paprika, cayenne pepper, garlic powder, onion powder, oregano, thyme, salt, and black pepper in a shallow dish until thoroughly combined.
05 - Remove chicken from marinade, allowing excess to drip off. Dredge each piece in seasoned flour, pressing firmly to adhere coating. Place on wire rack and rest for 10 minutes to set the breading.
06 - Heat 2 inches of vegetable oil in a heavy skillet to 350°F. Fry chicken in batches, turning occasionally, until golden brown and internal temperature reaches 165°F, approximately 15–18 minutes. Drain on wire rack.
07 - Arrange fried chicken and warm biscuits on a serving platter. Serve immediately while hot.